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KMID : 0355319920160010087
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Journal of Korean Academy of Oral Pathology
1992 Volume.16 No. 1 p.87 ~ p.100
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Autoradiographic study about effects of medicaments for pulpotomy on tooth germinal and perigerminal cell of rat by using H3-thymidine
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1임창윤/1Sam-Pyo Hong
1홍삼표/2이종헌/2박경주/1Chang-Yun Lim/2Gyeong-Ju Park/2Chong-Heon Lee
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Abstract
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-Abstract-
Formocresol(FC) had been widely used as medicament for pulpotomy, but because FC
hase strong toxicity, carcinogenic potential, and strong diffusible properties in tissues,
Glutaraldehyde, another medicament for pulpotomy was greatly presented by many
investigators and practitioners. Although many investigators had studied difference of
two medicament's effects on periodontal tissues and tooth germ, there were no
manuscripts of cellular activity about these medicaments applied to teeth, but there were
almost clinical, histopathological studies. Especially in the investigative effects on tooth
germ, the results were controversal. thus to investigate about effects on cellular activity
of perigerminal tissue and tooth germ of rat, author presented the cellular activity and
the pathologic change through calculating Thymidine labelling index(TLI) from
autoradiographic technique using H3-thymidine after these medicament
were applied to tooth. the obtained results were as follows.
1. Inflammation was initiated after one week of FC and two weeks of GA. It was
thought that diffusible property of GA was lesser than that of FC.
2. In group treated with FC, inflammation, vasodilation and bone destruction
continuously increased for all periods of experiment and the feature of 8weeks was very
severe. But in group treated with GA, inflammation, vasodilation and bone destruction
slightly increased for all periods of experiment.
3. TLI was increased after two weeks of FC, gut decreased after four weeks because of
different accumulative concentration between 2 and 4 weeks.
4. GA treated group which did not show the change of the cellular activity of
perigerminal tissue and tooth germ presented the slight effects on these cells.
5. Changes of cellular activites in FC treated group did not result from inflammation,
but the property of formocresol itself. And bone destruction was derived from secondary
effects of inflammation
6. The fact that FC arose sever inflammation and change of cellular activity reflected
that FC might affected the development of permanent successor.
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KEYWORD
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